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Union Minister Mansukh L Mandaviya said supply of the drug, which is being used to treat Covid-19, has been ramped up over ten times since 11 April.
Speaking in Kanpur, Yogi Adityanath also said properties of those hoarding or black-marketing life-saving medicines will be seized.
The court was hearing a PIL seeking lodging of an FIR on the allegations that politicians are procuring & distributing medicines as patients run from pillar to post to get them.
Lawyers against Covifraud and India pro bono lawyers are among the groups that have organised through social media to offer advice and aid to victims of pandemic-related frauds.
Dr Raman Gangakhedkar, face of ICMR during Covid briefings last year, said India could become breeding ground for several mutants if it does not adhere to evidence-based treatment.
The plea claimed that there are more than 25 companies in India which manufacture the medicine, but only 6 to 8 are permitted to sell it in the domestic market.
Demand for Remdesivir has gone up manifold in the country with a surge in Covid cases. The antiviral drug is used in the treatment of the infectious disease.
The high court said that the Centre was changing the protocol to reduce the shortage of remdesivir, adding that it was a 'complete mismanagement'.
The High Court also sought the Central govt response on the incident where BJP MP Sujay Vikhe Patil reportedly procured Remdesivir vials from Delhi and distributed them in the state.
As part of expanding the availability of remdesivir in India, drug firm Gilead Sciences said it is providing support to its licensees to expand their local manufacturing capacity.