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Moderna vaccine produces antibodies in trial of older people

The results from Moderna’s early-stage trial, which include data from 20 participants, are important because older adults often don’t respond as well to vaccines as younger adults.

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New York: Moderna Inc. presented new safety data from an early trial that provides the first evidence that its Covid-19 vaccine stimulates the immune systems of older people.

In a phase 1 trial, Moderna’s coronavirus vaccine produced “consistently high levels” of neutralizing antibodies — a key component of the body’s protective response — in older adults, the company said in a statement. Antibody levels produced in people more than 55 years old were comparable to those seen in younger adults, the company said in a statement.

The results from Moderna’s early-stage trial, which include data from 20 people in the older age group, were presented Wednesday to the U.S. Centers for Disease Control and Prevention’s Advisory Committee on Immunization Practices. The findings are important because older adults often don’t respond as well to vaccines as younger adults.

The trial used a dose of the vaccine that has advanced to a final-stage trial. The dose produced antibody levels higher than those typically seen in people recovering from the virus, Moderna said.

While the vaccine is associated with a variety of side effects, including chills, fatigue, fever, headache and muscle pain, there were no serious adverse events in the 100-microgram dose that’s being used in the final-stage trial, according to a copy of Moderna’s slide presentation from the meeting.

The company earlier published data from the same trial showing that the vaccine produced neutralizing antibodies against the coronavirus in younger adults. Triggering neutralizing antibodies in older patients is important as they are some of the most severely affected by Covid-19.

The Moderna vaccine is now in a large final-stage trial in the U.S., with results possible by late fall. The shares rose as much as 2.9% early in New York.-Bloomberg


Also read: Why some countries don’t want to wait for Covid vaccines from superpowers


 

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