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HomeScienceMMR vaccine doesn't increase autism risk, says Denmark study

MMR vaccine doesn’t increase autism risk, says Denmark study

Scientists at Statens Serum Institut also find that vaccines do not trigger autism in children who are at risk. Study comes amid fears of falling vaccination rates.  

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New Delhi: The measles, mumps, and rubella (MMR) vaccination does not increase the risk for autism nor does it trigger autism in children who are at risk, scientists in Denmark have found.

Scientists at the Copenhagen-based Statens Serum Institut (SSI) also found that MMR vaccination is not associated with the clustering of autism cases post-vaccination.

The study is the latest to dispel the myth that vaccination causes autism, first propagated in a 1998 research paper by Andrew Wakefield, which was published in the medical journal The Lancet.

Althought The Lancet retracted the paper in 2010, on the grounds that Wakefield had been “dishonest” with his findings, the 1998 paper had resulted in the decline of the vaccination rates across the globe.

In the latest findings, the SSI scientists examined over 6,50,000 children born in Denmark between 1999 and 2010. “During 5,025,754 person-years of follow-up, 6,517 children were diagnosed with autism — at an incidence rate of 129.7 per 1,00,000 person-years,” the study said. “Comparing MMR-vaccinated with MMR-unvaccinated children yielded a fully adjusted autism hazard ratio of 0.93.”

Their findings, published in the Annals of Internal Medicine Tuesday, concludes that “MMR vaccination does not increase the risk for autism, does not trigger autism in susceptible children and is not associated with clustering of autism cases after vaccination”.

Supported by pharma giant Novo Nordisk Foundation and the Danish Ministry of Health, the study observed that there is “no increased risk for autism after MMR vaccination in subgroups of children defined according to sibling history of autism, autism risk factors (based on a disease risk score) or other childhood vaccinations, or during specified time periods after vaccination”.

Medical experts said the study is significant because of its sample size and its timing.

“The concerns that there is a link between vaccines and autism has been disproved once again. Over the last 10 years, several studies have already shown that there is no link at all, and this study adds to them by studying over 65,000 subjects,” Sri Krishna, a research fellow at the Centre for Surgery, National Cancer Institute, USA, told ThePrint.

“This is timely because there has been a surge in anti-vaccination sentiment based on no scientific evidence in many countries. This study once again proves them wrong.”

Also read: New TB cases in India shot up by 16% in 2018 – but that’s not bad news

No clarity on effect in India

There is, however, no clarity on whether the new study will have an effect on vaccination rates in India, where there have been concerns over falling rates in some states.

For one, experts are themselves divided over whether the Wakefield study had any real impact on vaccination rates in India. Some like Oommen C. Kurian, fellow, Observer Research Foundation (ORF), believe it did.

“The Wakefield paper in 1998 was a potent weapon in the hands of anti-vaccination activists, even in India,” Kurian told ThePrint. “In many of our richer states, the vaccination coverage (across diseases) was impacted due to the misinformation when compared with the 2005 data,” he added.

“The invented link between the MMR vaccine and autism continued to cause concern and challenge in vaccine uptake in India, even after the paper was retracted,” Kurian said. “The paper was only one of the reasons behind falling vaccination coverage, as there could be various other reasons behind the poor performance of the states.”

Kurian quoted data from the National Family Health Survey (NFHS), which significantly showed that the immunisation coverage of Gujarat fell below most backward states — Bihar, Madhya Pradesh, Rajasthan and Uttar Pradesh (UP).

In 2005-06, Gujarat’s vaccination coverage was 45.2 per cent — above India’s average of 43.5 per cent. By 2015-16, the state’s immunisation rate was 50.4 per cent but 11.6 percentage points below the national average of 62 per cent.

The same government data showed that other rich states too showed a slump. Maharashtra posted a fall of 4.3 per cent in the number of children vaccinated in 2015-16 over 2005-06 while Tamil Nadu, credited for the highest rate of immunisation at 80.9 per cent in 2005-06, recorded only 69.1 per cent of children vaccinated in 2015-16.

“That was perhaps the single fake scientific paper in history with the highest human cost,” Kurian said.

“Despite the study getting retracted, anti-vaccine activists still use it, and hundreds of children are dying of Measles, a vaccine-preventable disease, just because their parents are made to think vaccination will lead to autism.”

Another vaccine expert said India only suffered due to ignorance about the importance of vaccines.

“I don’t think Wakefield study had any impact on Indian parents directly,” said Jacob Puliyel, a paediatrician at St Stephen’s Hospital, New Delhi.

“MMR is not part of the National Immunisation Programme in India. Some parents are sceptical about giving many vaccines to their babies after all the deaths following the Pentavalent vaccine in India.”

The new study may not increase the uptake of vaccination but will help doctors in convincing the parents, said Yogesh Jain, physician and public health activist at the NGO Jan Swasthya Sahyog in Chhattisgarh.

“It is confirmed now that MMR vaccine does not cause autism,” he said. “It may not result in a drastic increase of uptakes but the new study will help doctors to convince parents about the benefits of MMR vaccination.”

Also read: After giant pharma push, China keeps Indian drug makers waiting


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