Representational image | Cottonbro | Pexels
Representational image | Cottonbro | Pexels
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New Delhi: A vaccine for the coronavirus will likely be ready by early 2021 but rolling it out safely across India’s 1.3 billion people will be the country’s biggest challenge in fighting its surging epidemic, a leading vaccine scientist told Bloomberg.

India, which is host to some of the front-runner vaccine clinical trials, currently has no local infrastructure in place to go beyond immunizing babies and pregnant women, said Gagandeep Kang, professor of microbiology at the Vellore-based Christian Medical College and a member of the WHO’s Global Advisory Committee on Vaccine Safety.

The timing of the vaccine is a contentious subject around the world. In the U.S., President Donald Trump has contradicted a top administration health expert by saying a vaccine would be available by October. In India, Prime Minister Narendra Modi’s government had promised an indigenous vaccine as early as mid-August, a claim the government and its apex medical research body has since walked back.

For a country of its size, and with a virus curve that shows no sign of flattening, a safe and quick vaccine is a top priority for the Modi administration. The country’s broken health-care system, already struggling to deliver adequate care before the outbreak, cannot cope with the strain of a prolonged pandemic. A strict lockdown implemented in late March led to the biggest contraction among major economies with gross domestic product shrinking 23.9% in the three months to June from a year earlier.

“By year-end we will have data that will tell us which vaccines are working and which ones are not going to do so well,” said Kang, who until July was heading the Indian government committee looking into prospective indigenous vaccine candidates. “If we get good results by year-end then we are looking at vaccines being potentially available in tiny numbers in first half of 2021 and larger numbers in the latter part.”

Kang said that any vaccine currently in phase three trials, whether locally made or being tested by major western pharmaceutical companies, had a 50% chance of success.


Also read: ICMR denies sero survey hushed up data showing up to 48% Covid reach in hotspots in May


Immunization Challenges

India is hosting clinical trials for all the major vaccine contenders. Serum Institute of India, the world’s largest vaccine manufacturer, is conducting trials for the vaccine developed by Oxford University. The drugmaker Dr Reddy’s Laboratories said last week it will distribute the Russian vaccine in India after conducting final-stage human trials and receiving regulatory approval.

India’s indigenous vaccine developers Bharat Biotech International Ltd. are at the second-phase human trial stage and Zydus Cadila is in the process to receive approvals for conducting third-phase clinical trials.

Even after an effective vaccine is available, India will be staring at storage and delivery barriers as the outbreak escalates through the nation’s hinterland. The world’s second most populous country also has no experience of, and infrastructure for, mass immunization across age groups.

“We have no life cycle immunization structures, we have no way of vaccinating the elderly who are a particular risk group here,” said Kang. “Just building the system to be able to immunize all ages is going to be a challenge.”

Data Troubles

Even as the South Asian nation races to get access to a reliable vaccine to control its fast moving pandemic, its patchy testing strategy may end up underestimating the true extent of its outbreak.

India has been relying increasingly on quick antigen tests that can report false negatives as much as 50% of the time and its daily testing data doesn’t specify what type of tests — antigen or the more sensitive real time-polymerase chain reaction tests — make up the total or whether they were conducted on symptomatic or asymptomatic people, said Kang.

Despite boosting antigen tests, India’s 8% testing positivity rate is far higher than the World Health Organization’s 5% benchmark for controlling the outbreak.

“It seems at many places antigen and RT-PCR are being used interchangeably. That doesn’t make sense to me,” she said. “It’s hard to tell whether the rate at which cases are rising will accelerate when you don’t know the testing strategy in different states.”-Bloomberg


Also read: Reader View: People don’t have too many options but to trust a quickly-made Covid vaccine


 

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1 Comment Share Your Views

1 COMMENT

  1. The private sector should be roped in at the earliest, Govt does not have the money or the infrastructure to vaccinate the people in 1 year. The vaccine should be made commercially available and private hospitals, clinics, doctors etc encouraged to vaccinate the people, with a reasonable price cap. This will allow the Govt to focus on vaccinating the poor and people in remote areas.

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