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Vaccinations reduce chance of Covid death in India to 0.4%, says ICMR study

The findings underscore crucial role of vaccines in preventing extreme outcomes among Covid patients and allays doubts around vaccine efficacy, especially with respect to delta variant.

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Vaccines targeting Covid-19 are able to curb deaths and hospitalization in patients substantially, including those infected by the highly-transmissible delta variant that drove India’s devastating second wave and is now triggering curbs from Los Angeles to Melbourne.

About 0.4% died among those who got infected after inoculation — called breakthrough infections — while nearly 10% needed hospitalization, according to a new study by researchers led by Indian Council of Medical Research’s Nivedita Gupta. The study, which analyzed genome sequencing data of 677 Covid patients, found 86% of the fully-vaccinated cases were due to the delta variant.

The findings underscore the crucial role of shots in preventing extreme outcomes among Covid sufferers and allays doubts around vaccine efficacy especially with respect to the delta variant that has rapidly spread to at least 104 countries. First detected in India last October, this variant has emerged as the dominant strain in the U.K., the U.S. and Australia, forcing public health officials to double down on social distancing measures.

“This clearly suggests that vaccination reduces severity of disease, hospitalization and mortality,” said the study. “Therefore, enhancing the vaccination drive and immunizing the populations quickly would be the most important strategy to prevent further deadly waves of the Covid-19 and would reduce the burden on the health care system.”

Among those analyzed in the study, which is still to be peer-reviewed, 592 people had received both the vaccine doses while 85 had only one dose. India has predominantly injected people with AstraZeneca Plc’s Covishield — a traditional vector-based shot whose efficacy against the delta variant has been dogged with concerns compared to the highly-effective messenger RNA vaccines from Pfizer Inc. and Moderna Inc.

Delta Mutations

Possibly the largest and first nationwide study of post-vaccination breakthrough infections from India, the research also detected evidence of two new mutations of delta — Delta AY.1 and Delta AY.2 — in some samples besides older variants, alpha and kappa.

India saw daily infections breach record 400,000-levels in early May during the delta-driven second wave which overwhelmed hospitals and crematoriums. Shortages of essential supplies led to citizens’ pleas flooding social media platforms for hospital beds, oxygen cylinders and Covid-related medicines.

The country has so far fully vaccinated only 5.7% of its 1.3 billion population, according to Bloomberg’s vaccine tracker.

Third Wave

Infections are on the rise again in some Indian states including Maharashtra and Kerala, stoking fears of an incoming third wave. India’s Prime Minister Narendra Modi told state chiefs during a briefing Friday that effective steps were urgently needed to curb the outbreak from flaring up again.

The study also has policy prescriptions for India as it seeks to avert another of Covid infections. It emphasized the need for constant genome sequencing as well as tracking these breakthrough infections.

“Such monitoring will help us to understand the need to adequately tweak the available vaccines and also develop new vaccines with enhanced potential to protect against variant strains of SARS-CoV-2,” it said. – Bloomberg

Also read: Modi govt finally raises vaccine prices, will pay Rs 215 for Covishield, Rs 225 for Covaxin


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